We observed intralocus allelic heterogeneity but little evidence of low-frequency variants with larger effects and no evidence of synthetic association. In addition to confirming most known CAD-associated loci, we identified ten new loci (eight additive and two recessive) that contain candidate causal genes newly implicating biological processes in vessel walls. Leveraging phased haplotypes from the 1000 Genomes Project, we report a GWAS meta-analysis of ∼185,000 CAD cases and controls, interrogating 6.7 million common (minor allele frequency (MAF) > 0.05) and 2.7 million low-frequency (0.005 < MAF < 0.05) variants. Samani, Martin FarrallĪbstract = "Existing knowledge of genetic variants affecting risk of coronary artery disease (CAD) is largely based on genome-wide association study (GWAS) analysis of common SNPs. Thompson, Jeanette Erdmann, Robert Clarke, Hugh Watkins *, Sekar Kathiresan, Ruth McPherson, Panos Deloukas, Heribert Schunkert, Nilesh J. Ridker, Samuli Ripatti, Robert Roberts, Veikko Salomaa, Dharambir K.
Palmer, Markus Perola, Thomas Quertermous, Daniel J. Loos, Olle Melander, Andres Metspalu, Winfried März, Colin N. Harris, Stanley Hazen, Christian Hengstenberg, Albert Hofman, Erik Ingelsson, Carlos Iribarren, J. Granger, Dongfeng Gu, Vilmundur Gudnason, Alistair Hall, Anders Hamsten, Tamara B. Franco, Maria Grazia Franzosi, Christopher B. Chambers, Rory Collins, L Adrienne Cupples, John Danesh, Ilja Demuth, Roberto Elosua, Stephen E. Zaman, Diego Ardissino, Eric Boerwinkle, Ingrid B. Shah, Juha Sinisalo, Kathleen Stirrups, Stella Trompet, Laiyuan Wang, Khan S. Rallidis, Asif Rasheed, Maria Samuel, Svati H.
Mallick, Narinder Mehra, Thomas Meitinger, Fazal Uur Rehman Memon, Andrew P. König, Lars Lannfelt, Wolfgang Lieb, Lars Lind, Cecilia MLindgren, Marja Liisa Lokki, Patrik K. Goodall, Omri Gottesman, Marc Haber, Bok Ghee Han, Jianfeng Huang, Shapour Jalilzadeh, Thorsten Kessler, Inke R. Anand, Lars Bertram, Frank Beutner, George Dedoussis, Philippe Frossard, Dominique Gauguier, Alison H. Smith, Emmi Tikkanen, Andre Uitterlinden, Xueli Yang, Weihua Zhang, Wei Zhao, Mariza De Andrade, Paul S. Rose, Elias Salfati, Thomas Meitinger, Markus Scholz, Albert V. Morrison, Natalia Pervjakova, Liming Qu, Lynda M. Kleber, King Wai Lau, Xiangfeng Lu, Yingchang Lu, Leo Pekka Lyytikäinen, Evelin Mihailov, Alanna C. Chasman, Shufeng Chen, Ian Ford Show 131 more Show less Nora Franceschini, Christian Gieger, Christopher Grace, Stefan Gustafsson, Jie Huang, Shih Jen Hwang, Yun Kyoung Kim, Marcus E. Webb, Lingyao Zeng, Abbas Dehghan, Maris Alver, Sebastian MArmasu, Kirsi Auro, Andrew Bjonnes, Daniel I. Hall, Christina Willenborg, Stavroula Kanoni, Danish Saleheen, Theodosios Kyriakou, Christopher P. Majid Nikpay, Anuj Goel, Hong Hee Won, Leanne M.
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